Alzheimers Research Paper Preventing

Journal of Alzheimer’s Disease
Title: Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial.
Published 14 August 2017
Sindi S., Ngandu T., Hovatta I.,Kåreholt I., Antikainen R., Hänninen T., Levälahti E., Laatikainen T., Lindström J., Paajanen T., Peltonen M., Khalsa DS., Wolozin B., Strandberg T., Tuomilehto J., Soininen H., Kivipelto M., Solomon A., FINGER study group.

DOI: 10.3233/JAD-170123
https://www.ncbi.nlm.nih.gov/pubmed/28777749

Journal of Alzheimer’s Disease
Title: Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.
Published 3 February 2017
Innes, Kim E., Selfe, Terry Kita, Khalsa, Dharma Singh, Kandati, Sahitia.

DOI: 10.3233/JAD-160867
https://www.ncbi.nlm.nih.gov/pubmed/28106552

International Psychogeriatrics
Title: A Randomized Controlled Trial of Kundalini Yoga in Mild Cognitive Impairment
Published January 2017
Harris A. Eyre, Prabha Siddarth, Bianca Acevedo, Kathleen Van Dyk, Pattharee Paholpak, Linda Ercoli, Natalie St. Cyr, Hongyu Yang, Dharma S. Khalsa and Helen Lavretsky. International Psychogeriatrics

DOI: 10.1017/S1041610216002155
https://www.researchgate.net/publication/312383052_A_randomized_controlled_trial_of_Kundalini_yoga_in_mild_cognitive_impairment

Current Behavioral Neuroscience Reports

Title: The Neural Mechanisms of Meditative Practices: Novel Approaches for Healthy Aging.
Epub 18 October 2016
Acevedo, BP, Pospos, S, Lavretsky, H. Current Behavioral Neuroscience Reports. 2016;3(4):328-339. DOI: 10.1007/s40473-016-0098-x
https://www.ncbi.nlm.nih.gov/pubmed/27909646

Frontiers in Aging Neuroscience
Title: Neurochemical and Neuroanatomical Plasticity Following Memory Training and Yoga Interventions in Older Adults with Mild Cognitive Impairment
Published 21 November 2016
Hongyu Yang, Amber M. Leaver, Prabha Siddarth Pattharee Paholpak, Linda Ercoli, Natalie M. St. Cyr, Harris A. Eyre, Katherine L. Narr, Dharma S. Khalsa and Helen Lavretsky. Frontiers in Aging Neuroscience.
http://dx.doi.org/10.3389/fnagi.2016.00277

Journal of Alzheimer’s Disease
Title: Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study
Published in May 2016
Eyre, Harris A., Acevedo, Bianca. Yang, Hongyu, Siddarth, Prabha, Van Dyk, Kathleen, Ercoli, Linda, Leaver, Amber M., Cyr, Natalie St., Narr, Katherine, Baune, Bernhard T., Khalsa, Dharma S., Lavretsky, Helen. Journal of Alzheimer’s Disease, vol. 52, no. 2, pp. 673-684, 2016
DOI: 10.3233/JAD-150653
http://www.ncbi.nlm.nih.gov/pubmed/27060939

Complementary Therapies in Medicine
Title: A randomized controlled trial of two simple mind-body programs,
Kirtan Kriya meditation and music listening, for adults with subjective
cognitive decline: Feasibility and acceptability
Available online 5 March 2016
Kim E. Innes, Terry Kit Selfe, Dharma Singh Khalsa, Sahiti Kandati. Complementary Therapies in Medicine, 26 (2016) 98–107
http://dx.doi.org/10.1016/j.ctim.2016.03.002

Journal of Alzheimer’s Disease
Title: Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial.
Published online 8 April 2016
Kim Innes, Terry Kit Selfe, Dharma Singh Khalsa, Sahitia Kandati, Journal: Journal of Alzheimer’s Disease, vol. Preprint, no. Preprint, pp. 1-22, 2016
DOI: 10.3233/JAD-151106
http://www.ncbi.nlm.nih.gov/pubmed/27079708

Alternative and Complementary Therapies
Title: Integrative Therapies Essential for Addressing the Alzheimer’s Crisis: Foundation Awards $200,000 Grant to the University of New Mexico’s Section of Integrative Medicine
Moderator:, Hart Jane. Contributors:, Khalsa Dharma Singh, Prasad Arti, and Knoefel Janice.
Published Online Ahead of Print: January 20, 2016
February 2016, 22(1): 33-36. doi:10.1089/act.2015.29040.kpk.
http://online.liebertpub.com/doi/abs/10.1089/act.2015.29040.kpk

Journal of Alzheimer’s Disease
Title: Stress, Meditation, and Alzheimer’s Disease Prevention: Where the Evidence Stands
Dharma Singh Khalsa. Journal of Alzheimer’s Disease 48 (2015) 1-12 doi: 10.3233/JAD-142766
Published in July 2015
http://www.ncbi.nlm.nih.gov/pubmed/26445019
To read the entire article http://content.iospress.com/articles/journal-of-alzheimers-disease/jad142766

The Lancet
Title: A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu, Jenni Lehtisalo, Alina Solomon, Miia Kivipelto, et al.
Published online at thelancet.com on March 12, 2015
http://tinyurl.com/qztjdsh

Journal of Neuroengineering and Rehabilitation
Title: Interactive balance training integrating sensor-based visual feedback of movement performance: a pilot study in older adults
Michael Schwenk, Gurtej S Grewal, Bahareh Honarvar, Stefanie Schwenk, Jane Mohler, Dharma S Khalsa and Bijan Najafi. Journal of NeuroEngineering and Rehabilitation 2014, 11:164 doi:10.1186/1743-0003-11-164
Published: 13 December 2014
http://www.jneuroengrehab.com/content/11/1/164/abstract/

Advances in Mind Body Medicine
Title: The Pillars of Alzheimer’s Prevention
Khalsa, DS, Gustafson, C.
2014 Summer;28(3):26-32.
Published Summer 2014
http://www.ncbi.nlm.nih.gov/pubmed/25141356

Arizona Geriatrics Society Journal
Title: Kirtan Kriya Yoga Meditation: A New Dimension in Alzheimer’s Prevention
Khalsa, DS.
Arizona Geriatrics Society Journal. 2013; 18(2):12-16
Published October 2013

NIH Public Access, Author Manuscript
Title: Stress, Inflammation and Aging
Helen Lavretsky and Paul A. Newhouse.
Published September 1, 2013.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428505

Biochemical Pharmacology
Title: Future directions in Alzheimer’s disease from risk factors to prevention.
Imtiaz B, Tolppanen AM, Kivipelto M, Soininen H. Biochem Pharmacol. 2014 Apr 15;88(4):661-70. doi: 10.1016/j.bcp.2014.01.003. Epub 2014 Jan 10.
Published January 2013
http://www.ncbi.nlm.nih.gov/pubmed/24418410

Alzheimer’s & Dementia
Title: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress.
Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, et al. Alzheimers Dement. 2013 Jan 16. pii: S1552-5260(12)02523-X. doi: 10.1016/j.jalz.2012.09.012. [Epub ahead of print] Published in January 2013
http://www.ncbi.nlm.nih.gov/pubmed/23332672

Aging Health
Title: A Pilot Study On The Effects Of Meditation On Regional Brain Metabolism In Distressed Dementia Caregivers
Kelsey L Pomykala, Daniel HS Silverman, Cheri L Geist, Patricia Voege, Prabha Siddarth, Nora Nazarian,Natalie M St Cyr, Dharma S Khalsa & Helen Lavretsky Aging Health Aging Health, October 2012, Vol. 8, No. 5, Pages 509-516 , DOI 10.2217/ahe.12.46 (doi:10.2217/ahe.12.46)
Published in October 2012
http://www.futuremedicine.com/doi/abs/10.2217/ahe.12.46

Psychoneuroendocrinology
Title: Yogic Meditation Reverses NF-?b And IRF-Related Transcriptome Dynamics In Leukocytes Of Family Dementia Caregivers In A Randomized Controlled Trial
Black DS, Cole SW, Irwin MR, Breen E, St Cyr NM, Nazarian N, Khalsa DS, Lavretsky H. Psychoneuroendocrinology. 2012 Jul 13. [Epub ahead of print] Published in July 2012
http://www.ncbi.nlm.nih.gov/pubmed/22795617

International Journal of Geriatric Psychiatry
Title: A Pilot Study of Yogic Meditation for Family Dementia Caregivers with Depressive Symptoms: Effects on Mental Health, Cognition, and Telomerase Activity
Lavretsky H, Epel ES, Siddarth P, Nazarian N, Cyr NS, Khalsa DS, Lin J, Blackburn E, Irwin MR. Int J Geriatr Psychiatry. 2013 Jan;28(1):57-65. doi: 10.1002/gps.3790. Epub 2012 Mar 11.
Published in March 2012
http://www.ncbi.nlm.nih.gov/pubmed/22407663

Journal of Alternative and Complementary Medicine
Title: Effects of An 8-Week Meditation Program on Mood and Anxiety in Patients With Memory Loss
Moss AS, Wintering N, Roggenkamp H, Khalsa DS, Waldman MR, Monti D, Newberg AB. J Altern Complement Med. 2012 Jan;18(1):48-53. doi: 10.1089/acm.2011.0051.
Published in January 2012
http://www.ncbi.nlm.nih.gov/pubmed/22268968

Psychiatry Research: Neuroimaging
Title: Cerebral Blood Flow Changes Associated with Different Meditation Practices and Perceived Depth Of Meditation
Wang DJ, Rao H, Korczykowski M, Wintering N, Pluta J, Khalsa DS, Newberg AB. Psychiatry Res. 2011 Jan 30;191(1):60-7. doi: 10.1016/j.pscychresns.2010.09.011. Epub 2010 Dec 8.
Published in December 2010
http://www.ncbi.nlm.nih.gov/pubmed/21145215

Consciousness and Cognition
Title: Cerebral Blood Flow Differences Between Long-Term Meditators and Non-Meditators
Newberg AB, Wintering N, Waldman MR, Amen D, Khalsa DS, Alavi A. Conscious Cogn. 2010 Dec;19(4):899-905. doi: 10.1016/j.concog.2010.05.003. Epub 2010 Jun 8.
Published in May 2010
http://www.ncbi.nlm.nih.gov/pubmed/20570534

Journal of Alzheimer’s Disease
Title: Meditation Effects on Cognitive Function and Cerebral Blood Flow in Subjects with Memory Loss: A Preliminary Study
Newberg AB, Wintering N, Khalsa DS, Roggenkamp H, Waldman MR. J Alzheimers Dis. 2010;20(2):517-26. doi: 10.3233/JAD-2010-1391.
Published in April 2010
http://www.ncbi.nlm.nih.gov/pubmed/20164557

Nuclear Medicine Communications
Title: Cerebral Blood Flow Changes During Chanting Meditation
Khalsa DS, Amen D, Hanks C, Money N, Newberg A. Nucl Med Commun. 2009 Dec;30(12):956-61. doi: 10.1097/MNM.0b013e32832fa26c.
Published in June 2009
http://www.ncbi.nlm.nih.gov/pubmed/19773673

Journal of Alternative Therapies in Health and Medicine
Title: Integrated medicine and the prevention and reversal of memory loss.
Khalsa DS. Journal of Alternative Therapies in Health and Medicine
1998 Nov;4(6):38-43.
Published in November 1998
http://www.ncbi.nlm.nih.gov/pubmed/9810066

Journal of Alternative Therapies in Health and Medicine
Title: An Alternative Medical Program Is Effective in Patients with Cognitive Decline
Khalsa, DS. Journal of Alternative Therapies in Health and Medicine
1997 Vol 3, No. 4, Page 94

Proceedings of the Interstate Postgraduate Medical Association of North America Assembly
Stress-related illness. Where the evidence stands
Khalsa, DS. Interstate Postgraduate Medical Association of North America
1985 Nov 1;78(6):217-21.

The Alzheimer’s Research and Prevention Foundation’s Dr. Khalsa has also contributed to numerous books on Alzheimer’s Disease. See a list on our Book Chapters page.

How a healthy lifestyle can make a difference.


Image: shironosov/iStock

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of two types of protein in the brain: tangles (tau) and plaques (amyloid-beta). Eventually, Alzheimer's kills brain cells and takes people's lives.

Causes

What causes Alzheimer's? We still aren't sure. "For 1% of all cases, there are three genes that determine definitively whether or not you will have Alzheimer's, and all three relate to amyloid-beta production, which in these cases is likely the cause of Alzheimer's," says Dr. Gad Marshall, associate medical director of clinical trials at the Center for Alzheimer Research and Treatment at Harvard-affiliated Brigham and Women's Hospital. "For the other 99%, amyloid and tau are closely associated with Alzheimer's, but many things may contribute to the development of symptoms, such as inflammation in the brain, vascular risk factors, and lifestyle."

Improve your lifestyle

Healthy habits may help ward off Alzheimer's. Consider the following steps.

Exercise. "The most convincing evidence is that physical exercise helps prevent the development of Alzheimer's or slow the progression in people who have symptoms," says Dr. Marshall. "The recommendation is 30 minutes of moderately vigorous aerobic exercise, three to four days per week."

Eat a Mediterranean diet. "This has been shown to help thwart Alzheimer's or slow its progression. A recent study showed that even partial adherence to such a diet is better than nothing, which is relevant to people who may find it difficult to fully adhere to a new diet," says Dr. Marshall. The diet includes fresh vegetables and fruits; whole grains; olive oil; nuts; legumes; fish; moderate amounts of poultry, eggs, and dairy; moderate amounts of red wine; and red meat only sparingly.

Get enough sleep. "Growing evidence suggests that improved sleep can help prevent Alzheimer's and is linked to greater amyloid clearance from the brain," says Dr. Marshall. Aim for seven to eight hours per night.

Not as certain

We have some—but not enough—evidence that the following lifestyle choices help prevent Alzheimer's.

Learn new things. "We think that cognitively stimulating activities may be helpful in preventing Alzheimer's, but the evidence for their benefit is often limited to improvement in a learned task, such as a thinking skills test, that does not generalize to overall improvement in thinking skills and activities of daily living," says Dr. Marshall.

Connect socially. "We think that greater social contact helps prevent Alzheimer's," explains Dr. Marshall, but so far, "there is only information from observational studies."

Drink—but just a little. There is conflicting evidence about the benefit of moderate alcohol intake (one drink per day for women, one or two for men) and reduced risk of Alzheimer's. "It is thought that wine in particular, and not other forms of alcohol, may be helpful, but this has not been proved," says Dr. Marshall.

What you should do

Even though we don't have enough evidence that all healthy lifestyle choices prevent Alzheimer's, we do know they can prevent other chronic problems. For example, limiting alcohol intake can help reduce the risk for certain cancers, such as breast cancer. Best advice: make as many healthy lifestyle choices as you can. "They're all beneficial, and if they help you avoid Alzheimer's, all the better," says Dr. Marshall.

Know the symptoms of Alzheimer's

Forgetting where you parked your car can be annoying. If it happens all the time, it can be disturbing, and you may worry that it's a sign of a more serious condition. But don't panic. There's a difference between normal age-related memory slips, such as forgetting where the car keys are, and more serious signs of memory loss, such as forgetting what car keys are used for.

Early symptoms of Alzheimer's disease include frequent memory loss, confusion about locations, taking longer to accomplish normal daily tasks, trouble handling money and paying bills, loss of spontaneity, and mood and personality changes. "If you have a decline in your memory or thinking that affects your ability to perform any of your daily routines, ask your doctor for a screening to evaluate you for Alzheimer's and related conditions," says Dr. Gad Marshall, a Harvard Medical School assistant professor of neurology.

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